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The physiological relevance of the kinetic uncoupling is that it allows the formation of stable complexes, for example, with ironsulfur clusters or disulfide-bonded interaction partners
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For instance, administration must occur in a fasted state (at least 2-3 hours post-meal) because elevated insulin and blood glucose can significantly blunt the pituitarys response to secretagogues
This may improve overall health and well-being
These values are considered valid for both frozen and fresh blood samples
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